Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure: a randomized, controlled cross-over study.

@article{Arias2006PulmonaryHI,
  title={Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure: a randomized, controlled cross-over study.},
  author={Miguel A Arias and Francisco Garc{\'i}a-R{\'i}o and Alberto Alonso-Fern{\'a}ndez and I. Reinares Mart{\'i}nez and J. K. Sagardui Villamor},
  journal={European heart journal},
  year={2006},
  volume={27 9},
  pages={1106-13}
}
AIMS We tested the hypothesis that: (i) obstructive sleep apnoea (OSA) by itself originates pulmonary hypertension (PH); and (ii) the application of continuous positive airway pressure (CPAP) can reduce pulmonary pressure. METHODS AND RESULTS In this randomized and cross-over trial, 23 middle-aged OSA (apnoea-hypopnoea index, 44.1 +/- 29.3 h(-1)) and otherwise healthy patients and 10 control subjects were included. OSA patients randomly received either sham or effective CPAP for 12 weeks… CONTINUE READING

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