[Pulmonary hypertension in endothelial NO synthase knockout mice].

  • Yoichiro Hirata
  • Published 2001 in
    Nihon rinsho. Japanese journal of clinical…


Inhalation of nitric oxide (NO) effectively reduces pulmonary arterial pressure in patients with pulmonary hypertension. However, it is controversial as to the role of endothelium-derived NO in pulmonary hypertension. Disruption of endothelial NO synthase (eNOS) gene causes systemic hypertension and diminishes endothelium-dependent vasodilatation. Even at… (More)


Cite this paper

@article{Hirata2001PulmonaryHI, title={[Pulmonary hypertension in endothelial NO synthase knockout mice].}, author={Yoichiro Hirata}, journal={Nihon rinsho. Japanese journal of clinical medicine}, year={2001}, volume={59 6}, pages={1081-5} }