Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression.

  title={Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression.},
  author={Masaki Fujita and Robert J. Mason and C. Cool and John M. Shannon and Nobuyuki Hara and Karen A. Fagan},
  journal={Journal of applied physiology},
  volume={93 6},
Tumor necrosis factor-alpha (TNF-alpha) transgenic mice have previously been found to have characteristics consistent with emphysema and severe pulmonary hypertension. [] Key Method To determine whether sustained vasoconstriction was an important component of this pulmonary hypertension, nitric oxide was administered and hemodynamics were measured. Nitric oxide (25 ppm) failed to normalize right ventricular pressure in transgene-positive mice, suggesting that the pulmonary hypertension was not due to…

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