Pulmonary hemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group.

@article{Houten1992PulmonaryHI,
  title={Pulmonary hemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group.},
  author={John A Van Houten and William Long and Martha K Mullett and Neil Norman Finer and Dianne Derleth and bullet Mcmurray and Abraham Peliowski and David J Walker and Dawn Wold and Koravangattu Sankaran},
  journal={The Journal of pediatrics},
  year={1992},
  volume={120 2 Pt 2},
  pages={
          S40-4
        }
}
In an across study analysis of five multicenter, placebo-controlled trials of the synthetic surfactant, Exosurf Neonatal in infants weighing at least 700 gm, the incidence of clinical pulmonary hemorrhage was 1.9% in treated infants and 1.0% in control infants. To investigate whether a similar increase was also present histologically at postmortem examination, a blinded retrospective review of all autopsy reports from infants dying during these five trials was conducted. Pulmonary hemorrhage… CONTINUE READING

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