Pulmonary gas exchange during histamine-induced bronchoconstriction in asthmatic subjects.

  title={Pulmonary gas exchange during histamine-induced bronchoconstriction in asthmatic subjects.},
  author={T V Burke and M. K{\"u}ng and Nausherwan K. Burki},
  volume={96 4},
Bronchial provocation for testing airway hyperreactivity is now well-established. However, the effects of histamine-induced bronchoconstriction on pulmonary gas exchange in man have not been systematically studied. We empirically noted marked decreases in PaO2 in some asthmatic subjects following induced bronchoconstriction. Nine subjects with mild, stable asthma were studied, each on two separate days. The first determined the dose of inhaled histamine necessary to decrease FEV1 by 20 percent… 

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