Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.

@article{Wang2003PulmonaryEO,
  title={Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.},
  author={Jingming Wang and Qingsheng Chen and Jonathan Corne and Zhou Zhu and Chun Geun Lee and Vineet Bhandari and Robert J Homer and Jack A Elias},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={
          31226-32
        }
}
Leukemia inhibitory factor (LIF) is produced by a large number of pulmonary cells in response to diverse stimuli. Exaggerated levels of LIF have also been detected in the adult respiratory distress syndrome and other disorders. The biologic effects of LIF in the lung, however, have not been elucidated. To define the respiratory effects of LIF, we generated transgenic mice in which human LIF was selectively targeted to the mature lung. In these mice, transgene activation caused an impressive… CONTINUE READING

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