Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.

@article{Mercer2009PulmonaryEI,
  title={Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.},
  author={Paul F. Mercer and Robin H Johns and Chris J Scotton and Malvina A Krupiczojc and Melanie K{\"o}nigshoff and David C. Howell and Robin J McAnulty and Anuk M. Das and Andrew J. Thorley and Teresa D. Tetley and Oliver Eickelberg and Rachel C Chambers},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 5},
  pages={414-25}
}
RATIONALE Studies in patients and experimental animals provide compelling evidence of the involvement of the major thrombin receptor, proteinase-activated receptor-1 (PAR(1)), and the potent chemokine, chemokine (CC motif) ligand-2 (CCL2)/monocyte chemotactic protein-1, in the pathogenesis of idiopathic pulmonary fibrosis (IPF). PAR(1) knockout mice are protected from bleomycin-induced lung inflammation and fibrosis and this protection is associated with marked attenuation in CCL2 induction… CONTINUE READING
31 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…