Pulmonary epithelial cells are a source of interferon-gamma in response to Mycobacterium tuberculosis infection.

@article{Sharma2007PulmonaryEC,
  title={Pulmonary epithelial cells are a source of interferon-gamma in response to Mycobacterium tuberculosis infection.},
  author={Monika Sharma and Sanjay Sharma and Sugata Sen Roy and Saurabh N. Varma and Mridula Bose},
  journal={Immunology and cell biology},
  year={2007},
  volume={85 3},
  pages={
          229-37
        }
}
Recent report from our laboratory showed that A549 cells representing alveolar epithelial cells produce chemokine interleukin-8 and nitric oxide (NO) when challenged with Mycobacterium tuberculosis. Interferon-gamma (IFN-gamma) played a critical role in priming these cells to generate NO in vitro. In the present study, we report that M. tuberculosis-infected A549 cells are capable of elaborating IFN-gamma as shown by enzyme-linked immunosorbent assay and intracellular staining for IFN-gamma… CONTINUE READING

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