Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

@article{Lukic2016PulmonaryEC,
  title={Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.},
  author={Ana Lukic and Jie Ji and Helena Idborg and Bengt Samuelsson and Lena Palmberg and Susanne Gabrielsson and Olof R{\aa}dmark},
  journal={Journal of lipid research},
  year={2016},
  volume={57 9},
  pages={1659-69}
}
Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial cells. Monocytic cells (Mono Mac 6 cell line, primary dendritic cells) and eosinophils produced primarily LTC4 In coincubations of these myeloid cells and epithelial cells, LTD4 became a prominent product. LTC4 released from the myeloid cells was… CONTINUE READING
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