Pulmonary epithelial barrier function: some new players and mechanisms.

  title={Pulmonary epithelial barrier function: some new players and mechanisms.},
  author={Kieran A. Brune and James A. Frank and Andreas Schwingshackl and James H. Finigan and Venkataramana K Sidhaye},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={308 8},
The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal contents to the subepithelium. In addition, the epithelium dictates the initial responses of the lung to both infectious and noninfectious stimuli. One mechanism by which the epithelium does this is by coordinating transport of diffusible molecules across the epithelial barrier, both through the cell and between cells. In this review, we will discuss a few emerging paradigms of permeability changes through… CONTINUE READING
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