Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase.

@article{Dudek2004PulmonaryEC,
  title={Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase.},
  author={Steven M. Dudek and Jeffrey R. Jacobson and Eddie T. Chiang and Konstantin G Birukov and Peiyi Wang and Xi Zhan and Joe G. N. Garcia},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 23},
  pages={24692-700}
}
We recently reported the critical importance of Rac GTPase-dependent cortical actin rearrangement in the augmentation of pulmonary endothelial cell (EC) barrier function by sphingosine 1-phosphate (S1P). We now describe functional roles for the actin-binding proteins cortactin and EC myosin light chain kinase (MLCK) in mediating this response. Antisense down-regulation of cortactin protein expression significantly inhibits S1P-induced barrier enhancement in cultured human pulmonary artery EC as… CONTINUE READING
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