Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.

@article{Dudek2007PulmonaryEC,
  title={Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.},
  author={Steven M. Dudek and S. Michael Camp and Eddie T. Chiang and Patrick A. Singleton and Peter V. Usatyuk and Yutong Zhao and Viswanathan Natarajan and Joe G. N. Garcia},
  journal={Cellular signalling},
  year={2007},
  volume={19 8},
  pages={1754-64}
}
Novel therapeutic strategies are needed to reverse the loss of endothelial cell (EC) barrier integrity that occurs during inflammatory disease states such as acute lung injury. We previously demonstrated potent EC barrier augmentation in vivo and in vitro by the platelet-derived phospholipid, sphingosine 1-phosphate (S1P) via ligation of the S1P1 receptor. The S1P analogue, FTY720, similarly exerts barrier-protective vascular effects via presumed S1P1 receptor ligation. We examined the role of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2017

Similar Papers

Loading similar papers…