Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia.

@article{Mychaliska2004PulmonaryEE,
  title={Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia.},
  author={George B. Mychaliska and Susan M Officer and Catherine K Heintz and Barry C. Starcher and Richard A. Pierce},
  journal={Journal of pediatric surgery},
  year={2004},
  volume={39 5},
  pages={666-71}
}
BACKGROUND/PURPOSE Babies with congenital diaphragmatic hernia (CDH) suffer from pulmonary hypoplasia and pulmonary hypertension. Elastin is a critical component of the extracellular matrix (EM) involved in pulmonary development and mechanics. Because CDH lungs are developmentally immature and have reduced compliance, the authors hypothesized that elastin deposition would be reduced and disorganized in the nitrofen rat model of CDH. METHODS Time-dated pregnant Sprague-Dawley rats were fed 100… CONTINUE READING