Pulmonary effects of inhaled zinc oxide in human subjects, guinea pigs, rats, and rabbits.

@article{Gordon1992PulmonaryEO,
  title={Pulmonary effects of inhaled zinc oxide in human subjects, guinea pigs, rats, and rabbits.},
  author={Terry J Gordon and Lung-chi Chen and Janelle M. Fine and Richard Schlesinger and Wei Yan Su and T A Kimmel and M O Amdur},
  journal={American Industrial Hygiene Association journal},
  year={1992},
  volume={53 8},
  pages={503-9}
}
Occupational exposure to freshly formed zinc oxide (ZnO) particles (less than 1.0 micron aerodynamic diameter) produces a well-characterized response known as metal fume fever. An 8-hr threshold limit value (TLV) of 5 mg/m3 has been established to prevent adverse health effects because of exposure to ZnO fumes. Because animal toxicity studies have demonstrated pulmonary effects near the current TLV, the present study examined the time course and dose-response of the pulmonary injury produced by… CONTINUE READING
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