Pulmonary effects of continuous endotoxin infusion in the rat.

@article{Simons1991PulmonaryEO,
  title={Pulmonary effects of continuous endotoxin infusion in the rat.},
  author={Roy K. Simons and Ronald V. Maier and Emil Y. Chi},
  journal={Circulatory shock},
  year={1991},
  volume={33 4},
  pages={
          233-43
        }
}
A major hindrance to the elucidation of the pathogenesis of the adult respiratory distress syndrome (ARDS) is the lack of an animal model consistent with the clinical course in humans. A continuous intravenous infusion of endotoxin (LPS) over a several day period was used to more closely parallel the clinical setting. Male Sprague-Dawley rats infused with LPS via indwelling right atrial catheters become tachypneic, lethargic and anorectic with a steady loss in body weight. Serial blood gas… CONTINUE READING

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