Pulmonary edema and emphysema in cattle after intraruminal and intravenous administration of 3-methylindole.

@article{Carlson1975PulmonaryEA,
  title={Pulmonary edema and emphysema in cattle after intraruminal and intravenous administration of 3-methylindole.},
  author={James Reynolds Carlson and Ephraim Dickinson and Melvin T Yokoyama and Beverly J. Bradley},
  journal={American journal of veterinary research},
  year={1975},
  volume={36 9},
  pages={1341-7}
}
Intraruminal and intravenous administration of 3-methylindole (3MI; skatole) caused interstitial pulmonary edema and emphysema in cattle. In 3 adult heifers given the intraruminal dose of 0.2 g of 3 MI per kilogram of body weight, clinical signs of respiratory disease appeared between 6 and 12 hours after dosing, and death due to pulmonary edema and emphysema occurred at 33, 69, and 72 hours. The mean plasma concentration of 3MI became maximal (18.5 mug/ml) at 3 hours and then decreased to low… CONTINUE READING