Pulmonary distribution of nanoceria: comparison of intratracheal, microspray instillation and dry powder insufflation.

@article{Molina2016PulmonaryDO,
  title={Pulmonary distribution of nanoceria: comparison of intratracheal, microspray instillation and dry powder insufflation.},
  author={Ramon M Molina and Nagarjun V. Konduru and Hugo Hirano and Thomas C. Donaghey and Benoit Adamo and Brendan Laurenzi and Georgios Pyrgiotakis and Joseph D. Brain},
  journal={Inhalation toxicology},
  year={2016},
  volume={28 12},
  pages={550-560}
}
Particles can be delivered to the respiratory tract of animals using various techniques. Inhalation mimics environmental exposure but requires large amounts of aerosolized NPs over a prolonged dosing time, varies in deposited dose among individual animals, and results in nasopharyngeal and fur particle deposition. Although less physiological, intratracheal (IT) instillation allows quick and precise dosing. Insufflation delivers particles in their dry form as an aerosol. We compared the… CONTINUE READING
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