Pulmonary disposition of tobramycin.

  title={Pulmonary disposition of tobramycin.},
  author={Andrew C. Braude and Adriana Hornstein and Maja Klein and Stephen I Vas and A. S. Rebuck},
  journal={The American review of respiratory disease},
  volume={127 5},
Each antibiotic has a characteristic penetration into respiratory secretions, influenced by serum concentration, protein binding, transport systems, and the presence of infection. Whereas previous studies have used only bronchial secretions and blood, in the present study, blood, bronchial secretions, and bronchoalveolar lavage (BAL) fluid were analyzed for tobramycin levels. In 10 studies in 9 patients, serum levels were significantly related to BAL fluid levels (r = 0.8, p less than 0.01… CONTINUE READING


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