Pulmonary diffusing capacities for oxygen-labeled CO2 and nitric oxide in rabbits.

@article{Heller1998PulmonaryDC,
  title={Pulmonary diffusing capacities for oxygen-labeled CO2 and nitric oxide in rabbits.},
  author={Hartmut Heller and Gabriel Fuchs and Klaus-Dieter Schuster},
  journal={Journal of applied physiology},
  year={1998},
  volume={84 2},
  pages={
          606-11
        }
}
We determined the pulmonary diffusing capacity (DL) for 18O-labeled CO2 (C18O2) and nitric oxide (NO) to estimate the membrane component of the respective gas conductances. Six anesthetized paralyzed rabbits were ventilated by a computerized ventilatory servo system. Single-breath maneuvers were automatically performed by inflating the lungs with gas mixtures containing 0.9% C18O2 or 0.05% NO in nitrogen, with breath-holding periods ranging from 0 to 1 s for C18O2 and from 2 to 8 s for NO. The… 

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Pulmonary membrane diffusing capacity and capillary blood volume measured during exercise from nitric oxide uptake.

Results support DLNO as a direct measure of pulmonary membrane diffusing capacity, allowing the estimation of Vc in a single rebreathing maneuver during exercise, and can be applied clinically in the investigation of pulmonary microvascular regulation.

Labeled carbon dioxide (C18O2): an indicator gas for phase II in expirograms.

Overall, power moment analysis provides a more comprehensive view on phase II of single-breath expirograms than conventional dead space volume determinations and may be useful for respiratory physiology studies as well as for the study of diseased lungs.

Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia.

It is concluded thathyperoxia induces iNOS expression in the lung without an increase in NO concentration in the exhaled air, suggesting that NO is not synthesized in rats exposed to hyperoxia.

Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia.

It is concluded thathyperoxia induces iNOS expression in the lung without an increase in NO concentration in the exhaled air, suggesting that NO is not synthesized in rats exposed to hyperoxia.

How to calculate the single-breath nitric oxide diffusing capacity in rabbits

The deviation betweenDL,NO calculated from the conventional methods and the reference decreased linearly with increasing duration of NO uptake (Δt), qualifying the common prediction that the latter method yields DL,NO values of the highest accuracy.

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