Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice.

@article{Amorij2007PulmonaryDO,
  title={Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice.},
  author={J-P. Amorij and Vinay Saluja and Arjen H. Petersen and Wouter L. J. Hinrichs and Anke Huckriede and Henderik Willem Frijlink},
  journal={Vaccine},
  year={2007},
  volume={25 52},
  pages={8707-17}
}
In this study pulmonary vaccination with a new influenza subunit vaccine powder was evaluated. Vaccine powder was produced by spray-freeze drying (SFD) using the oligosaccharide inulin as stabilizer. Immune responses after pulmonary vaccination of BALB/c mice with vaccine powder were determined and compared to those induced by intramuscular and pulmonary vaccination with a conventional liquid subunit vaccine. All vaccinations were performed without adjuvant. Pulmonary vaccination with liquid… CONTINUE READING

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