Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.

  title={Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.},
  author={Nikos Oikonomou and Marios-Angelos Mouratis and Argyrios Tzouvelekis and Eleanna T Kaffe and Christos Valavanis and George Vilaras and A. K. Karameris and Glenn D. Prestwich and Demosthenes E Bouros and Vassilis Aidinis},
  journal={American journal of respiratory cell and molecular biology},
  volume={47 5},
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) concentrations have been reported in the alveolar space of both idiopathic pulmonary fibrosis patients and a corresponding animal model, whereas the genetic deletion or pharmacological inhibition of LPA receptor 1 attenuated the development of the modeled disease, suggesting a direct involvement of LPA in disease… CONTINUE READING

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