Pulmonary aspergillosis: a clinical review

  title={Pulmonary aspergillosis: a clinical review},
  author={Mohammad Kousha and Ratna Tadi and A O Soubani},
  journal={European Respiratory Review},
  pages={156 - 174}
Aspergillus is a mould which may lead to a variety of infectious, allergic diseases depending on the host's immune status or pulmonary structure. Invasive pulmonary aspergillosis occurs primarily in patients with severe immunodeficiency. The significance of this infection has dramatically increased with growing numbers of patients with impaired immune state associated with the management of malignancy, organ transplantation, autoimmune and inflammatory conditions; critically ill patients and… 

Pulmonary Aspergillosis: A Review on Diagnosis and Management

The pulmonary manifestations of Aspergillus infection, its diagnosis and treatments are discussed in this review of literature.

Diagnosis and treatment of pulmonary aspergillosis syndromes.

Improvement in outcomes for Aspergillus pulmonary syndromes requires that physicians recognize the varied and sometimes subtle presentations, be aware of populations at risk of illness, and institute potentially life-saving therapies early in the disease course.

Pulmonary aspergillosis.

The emergence of Aspergillus species in chronic respiratory disease.

It is proposed that understanding the complex interplay between host and fungi may provide key insights into the pathogenesis of Aspergillus-associated pulmonary syndromes in the setting of chronic lung disease, and provide novel therapeutic approaches to improve its identification and management.


This article reviews comprehensively the spectrum of diseases (aspergillosis) caused by Aspergillus spp, the commonest pathogenic form being the A. fumigatus, which is associated with significant mortality and morbidity, the prevalence appears to be on the increase.

Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient

A 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission and had a fatal outcome.

Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis

Clinically, patients with ABPA experience difficulty breathing; exacerbations of disease and are at high risk for bronchiectasis and lung fibrosis, so oral corticosteroids and antifungal agents are used to reduce fungal burden and lower the exposure to fungal antigens.

Invasive pulmonary aspergillosis: A case report [Aspergilosis pulmonar invasiva: Reporte de un caso]

In pediatric patients with hematological diseases who present with febrile neutropenia and respiratory symptoms, it is essential to consider fungi as potential etiologic agents including Aspergillus spp.

Pulmonary Aspergillosis: Spectrum of Disease.




Pulmonary aspergillosis: a clinical update.

  • O. ZmeiliA. Soubani
  • Medicine, Biology
    QJM : monthly journal of the Association of Physicians
  • 2007
A clinical update on the epidemiology, risk factors, clinical presentation, diagnosis and management of the major syndromes associated with pulmonary aspergillosis is provided.

Chronic forms of pulmonary aspergillosis.

  • D. Denning
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2001
In asthmatic patients and those with cystic fibrosis, allergic bronchopulmonary aspergillosis (ABPA) is a complication that reduces pulmonary function and, in asthmatics, is substantially improved by itraconazole therapy.

Chronic Necrotizing Pulmonary Aspergillosis: A Discrete Clinical Entity

We conclude that chronic necrotizing pulmonary aspergillosis is a clinical entity which has not usually been recognized as one of the forms of pulmonary disease due to Aspergillus species. Patients

Pulmonary aspergillosis in the acquired immunodeficiency syndrome.

Pulmonary aspergillosis is a possible late complication of AIDS; if diagnosed early, it may be treated successfully.

The spectrum of pulmonary aspergillosis.

  • W. Gefter
  • Medicine, Biology
    Journal of thoracic imaging
  • 1992
The various types of aspergillosis can be regarded as constituting a continuous spectrum, ranging from invasive disease in the severely immunosuppressed patient to hypersensitivity reactions such as allergic bronchopulmonary asperGillosis (and bronchocentric granulomatosis) in the hyperreactive patient.

Noninvasive Aspergillus pulmonary disease.

  • M. Judson
  • Medicine, Biology
    Seminars in respiratory and critical care medicine
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Allergic bronchopulmonary aspergillosis is a form of asthma associated with a Type I, III, and IV allergic response to Aspergillus antigens, which presents clinically as asthma but is also associated with bronchiectasis, airway destruction, and permanent lung injury if inadequately treated.

Noninvasive pulmonary Aspergillus infections.

Diagnosing fungal infections in immunocompromised hosts.

There is no single "gold standard" for diagnosing deepFungal disease, a problem that has bedevilled the proper evaluation of fungal disease and its treatment.

Concurrent allergic bronchopulmonary aspergillosis and aspergilloma: is it a more severe form of the disease?

  • A. Shah
  • Medicine, Biology
    European Respiratory Review
  • 2010
The mould Aspergillus, a genus of spore forming fungi, affects the respiratory system in more ways than one and causes a wide spectrum of chest radiographic appearances, which could be either transient or permanent.