Pulmonary arterial hypertension and the Enigma code of smouldering inflammation.


“What causes fever?” was the question that prompted the work that led to the discovery of the “leukocyte pyrogen”, eventually named interleukin (IL)-1, in the late 1970s [1]. However, despite the rapid understanding of innate and adaptive immune responses and inflammation during the 1980s, it was not until 1995 that HUMBERT et al. [2] reported that both IL… (More)
DOI: 10.1183/13993003.00996-2016