Pulmonary arterial hypertension: a disease of tethers, SNAREs and SNAPs?

@article{Sehgal2007PulmonaryAH,
  title={Pulmonary arterial hypertension: a disease of tethers, SNAREs and SNAPs?},
  author={Pravin B Sehgal and Somshuvra Mukhopadhyay},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 1},
  pages={H77-85}
}
Histological and electron microscopic studies over the past four decades have highlighted "plump," "enlarged" endothelial, smooth muscle, and fibroblastic cellular elements with increased endoplasmic reticulum, Golgi stacks, and vacuolation in pulmonary arterial lesions in human and in experimental (hypoxia and monocrotaline) pulmonary arterial hypertension. However, the contribution of disrupted intracellular membrane trafficking in the pathobiology of this disease has received insufficient… CONTINUE READING