Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis.

@article{Judge2006PulmonaryAO,
  title={Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis.},
  author={Eoin P Judge and Jonathan Dermot Dodd and James B. Masterson and Charles G. Gallagher},
  journal={Chest},
  year={2006},
  volume={130 5},
  pages={1424-32}
}
BACKGROUND FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF. METHODS The HRCT scans of 39 consecutive patients (19 males and 20 females; mean age, 22 years; range, 16 to 48 years) with two HRCT scans > 18 months apart were randomly and… CONTINUE READING

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