Pulmonary abnormalities due to ABCA1 deficiency in mice.

@article{Bates2005PulmonaryAD,
  title={Pulmonary abnormalities due to ABCA1 deficiency in mice.},
  author={Sandra R. Bates and J Q Tao and Heidi L Collins and Omar L. Francone and George H. Rothblat},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 6},
  pages={L980-9}
}
Mice gene targeted for ATP-binding cassette transporter A1 (ABCA1; Abca1(-/-)) have been shown to have low-serum high-density lipoprotein and abnormal lung morphology. We examined alterations in the structure and function of lungs from -/- mice (DBA1/J). Electron microscopy of the diseased mouse lung revealed areas of focal disease confirming previous results (47). Lipid analysis of the lung tissue of -/- mice showed a 1.2- and 1.4-fold elevation in total phospholipid (PL) and saturated… CONTINUE READING

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