Pulmonary Response to Surface-Coated Nanotitanium Dioxide Particles Includes Induction of Acute Phase Response Genes, Inflammatory Cascades, and Changes in MicroRNAs: A Toxicogenomic Study

@inproceedings{Halappanavar2011PulmonaryRT,
  title={Pulmonary Response to Surface-Coated Nanotitanium Dioxide Particles Includes Induction of Acute Phase Response Genes, Inflammatory Cascades, and Changes in MicroRNAs: A Toxicogenomic Study},
  author={Sabina Halappanavar and Petra A Jackson and Andrew L. Williams and Keld Alstrup Jensen and Karin S Hougaard and Ulla Vogel and Carole Lynn Yauk and H{\aa}kan Wallin},
  booktitle={Environmental and molecular mutagenesis},
  year={2011}
}
Titanium dioxide nanoparticles (nanoTiO(2) ) are used in various applications including in paints. NanoTiO(2) inhalation may induce pulmonary toxicity and systemic effects. However, the underlying molecular mechanisms are poorly understood. In this study, the effects of inhaled surface-coated nanoTiO(2) on pulmonary global messenger RNA (mRNA) and microRNA (miRNA) expression in mouse were characterized to provide insight into the molecular response. Female C57BL/6BomTac mice were exposed for 1… CONTINUE READING

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