Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene.

@article{Mai2007PulmonaryMA,
  title={Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene.},
  author={Huong Nguen Thi Mai and Minako Hijikata and Yusuke Inoue and Katsuhiro Suzuki and Mitsunori Sakatani and Mizuho Okada and Kazuya Kimura and Nobuyoshi Kobayashi and Emiko Toyota and Ko Kudo and Hideaki Nagai and Atsuyuki Kurashima and Akira Kajiki and Norihiro Oketani and Hiroshi Hayakawa and Gaku Tanaka and Junko Shojima and Ikumi Matsushita and Shinsaku Sakurada and Katsushi Tokunaga and Naoto Keicho},
  journal={The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  year={2007},
  volume={11 7},
  pages={808-13}
}
BACKGROUND The T5 allele in intron 8 (IVS8) on specific haplotype backgrounds (e.g., long TG repeats) causes abnormal splicing in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and is also known to be associated with chronic airway diseases. OBJECTIVE To investigate the role of CFTR variations for susceptibility to pulmonary Mycobacterium avium complex (MAC) infection. PARTICIPANTS Three hundred patients with pulmonary MAC infection (72 males, 228 females; mean age at… CONTINUE READING

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