Pulmonary Langerhans cell histiocytosis associated with Hodgkin's lymphoma

@article{Feuillet2010PulmonaryLC,
  title={Pulmonary Langerhans cell histiocytosis associated with Hodgkin's lymphoma},
  author={S{\'e}verine Feuillet and L. R. Port Louis and Anne Bergeron and Alice B{\'e}r{\'e}zn{\'e} and M L Dubreuil and Marc Polivka and {\'E}ric Oksenhendler and Abdellatif Tazi},
  journal={European Respiratory Review},
  year={2010},
  volume={19},
  pages={86 - 88}
}
To the Editor: Adult pulmonary Langerhans cell histiocytosis (LCH) is a rare disorder of unknown aetiology that occurs predominantly in young smokers with a peak incidence occurring between 20 to 40 yrs of age. High-resolution computed tomography (HRCT) of the chest is essential for diagnosis and typically shows a combination of nodules and cavitated nodules in addition to thick- and thin-walled cysts. Few case reports of pulmonary LCH following diagnosis of Hodgkin’s lymphoma (HL) have been… 
[Pulmonary manifestations of Langerhans cell histiocytosis].
A RARE CASE OF PULMONARY LANGERHANS CELL HISTIOCYTOSIS OCCURRING FOLLOWING HODGKIN’S LYMPHOMA
TLDR
A rare case of Pulmonary Langerhans Cell Histiocytosis occurring after partial treatment for nodular sclerosis Hodgkin's lymphoma is described, diagnosed while follow up investigations of Hodgkin’s disease and patient presented as pulmonary LCH with residual/recurrent Hodgkins disease.
How I manage pulmonary Langerhans cell histiocytosis
TLDR
Patients with advanced PLCH who complain of unexplained dyspnoea with decreased diffusing capacity of the lung for carbon monoxide should be screened for pulmonary hypertension by Doppler echocardiography, which must be confirmed by right heart catheterisation.
Pulmonary Langerhans Cell Histiocytosis: An Update From the Pathologists' Perspective.
  • A. Roden, E. Yi
  • Medicine
    Archives of pathology & laboratory medicine
  • 2016
TLDR
Given that the lesional cells of PLCH express BRAF in some patients, MAPKinase pathway-targeted treatment might be useful for therapy-resistant patients, as well as the basic diagnostic approach to PLCH.
Pulmonary langerhans cell histiocytosis
TLDR
All smokers with PLCH must be counseled on the importance of smoking cessation, which may result in regression of disease and obviate the need for systemic immunosuppressive therapy.
Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis
TLDR
Although the observed blood laboratory abnormalities were not specifically related to LCH, performing these tests in the diagnostic workup for PLCH is useful because some of these alterations may impact patient management.
Pulmonary Langerhans cell histiocytosis masquerading as adenocarcinoma of the lung.
TLDR
Among adults, it usually occurs in association with smoking, either as a unifocal eosinophilic granuloma (approximately one-third of patients), or by affecting multiple organ systems; lungs and bones are the most commonly involved sites.
Coexistence of Langerhans cell histiocytosis, Rosai–Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver
TLDR
The case of a 68‐year‐old man which presented an exceptional association of cutaneous LCH and RDD and splenic marginal zone lymphoma and pre‐mortem biopsy showed infiltration with histiocytic sarcoma is reported, and it is thought that a transdifferentiation phenomenon could explain the case.
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TLDR
Improved understanding of the mechanisms involved in the pathogenesis of pulmonary Langerhans’ cell histiocytosis is urgently needed, and should help in the development of specific therapeutic strategies for patients with this orphan disease.
Primary pulmonary histiocytosis X in two patients with Hodgkin's disease
TLDR
It is impossible to state with certainty whether the pulmonary histiocytosis arose as a response to the defects of cell-mediated immunity, or as a consequence of immunosuppression by radiation and chemotherapy, in patients with Hodgkin's disease.
Histiocytosis X arising in Hodgkin's disease: immunophenotypic characterization with a panel of monoclonal antibodies
TLDR
The results indicate that HX cells express HLA class I and II, including locus A, locus B and DP, DQ, DR, and detectable levels of ICAM-1 but not vitronectin receptors, and the possibility of the association of HX and Hodgkin's lymphoma extending the immunophenotypic profile of Hx cells is stressed.
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Aggressive Langerhans cell histiocytosis following T‐ALL: Clonally related neoplasms with persistent expression of constitutively active NOTCH1
TLDR
Persistent expression of NOTCH1 in such tumors suggests that Notch pathway inhibitors could have a role in the treatment of these unusual neoplasms.
Miliary Nodules, Hodgkin's Disease, and Eosinophilic Granuloma
We describe a patient with Hodgkin's disease (HD) who subsequently developed miliary lung nodules proven to be eosinophilic granuloma (EG). The differential diagnosis and a brief review of the
Association of langerhans cell histiocytosis with malignant neoplasms
TLDR
The association of Langerhans cell histiocytosis with a malignant neoplasm is rare and generally has been the subject of isolated case reports.
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