Pulmonary Hemodynamics and Plasma Endothelin-1 during Hypoxemia and Reoxygenation with Room Air or 100% Oxygen in a Piglet Model

@article{Medb1998PulmonaryHA,
  title={Pulmonary Hemodynamics and Plasma Endothelin-1 during Hypoxemia and Reoxygenation with Room Air or 100% Oxygen in a Piglet Model},
  author={Sverre Medb\o and Xiang-qing Yu and Anders {\AA}sberg and Ola Didrik Saugstad},
  journal={Pediatric Research},
  year={1998},
  volume={44},
  pages={843-849}
}
The immediate effect on the pulmonary circulation of reoxygenation with either room air or 100% O2 was studied in newborn piglets. Hypoxemia was induced by ventilation with 8% O2 until base excess was <-20 mmol/L or mean arterial blood pressure was <20 mm Hg. Reoxygenation was performed with either room air (n = 9) or 100% O2 (n = 9). Mean pulmonary artery pressure increased during hypoxemia (p = 0.012). After 5 min of reoxygenation, pulmonary artery pressure increased further from 24 ± 2 mm Hg… CONTINUE READING