Pulmonary Fibrosis Effect of Ammonium Perchlorate Exposure in Rabbit

  title={Pulmonary Fibrosis Effect of Ammonium Perchlorate Exposure in Rabbit},
  author={Feng-hong Wu and Hong-xia Chen and Xuan Zhou and Rao Zhang and Miao-hong Ding and Qin Liu and K. Peng},
  journal={Archives of Environmental \& Occupational Health},
  pages={161 - 165}
ABSTRACT Ammonium perchlorate (AP) is a kind of inorganic chemical. To evaluate the potential pulmonary fibrosis caused by occupational exposure to this compound, 25 male rabbits were randomly allocated into 5 groups to receive AP or bleomycin or saline by intratracheal injection. All rabbits were sacrificed and lung tissues were removed to prepare hematoxylin and eosin (HE) staining for microscope observation and to perform electron microscopy examine. In microscope observation, AP-instilled… Expand
Wildlife Toxicity Assessment for Perchlorate
As might be expected, amphibians appear to be the most sensitive class, but values for mammals and birds are higher and comparable to one another, and values for reptiles could not be calculated due to the lack of suitable data. Expand
Enhanced anion sensing by γ-irradiated polyphenol capped iron oxide nanoparticles
Abstract A novel method was designed for the synthesis of polyphenol capped amorphous iron oxide nanoparticles (ION) using an agro waste (peanut skin). The synthesized nanoparticles wereExpand
Faut-il craindre les ions perchlorate dans l’environnement ?
La majoration de l’apport iode des populations a risque est susceptible of contrecarrer les effets potentiels des ions perchlorate mais aussi d’autres inhibiteurs du symporteur a l”origine d”un effet cocktail. Expand


[Study on the injury effect of ammonium perchlorate to lung].
There were acute injury effect about AP to lung, but this experiment could not make sure whether AP could cause pulmonary fibrosis, and AP could affect the levels of MDA, HYP and the synthesis of collagen. Expand
Morphological Effect of Ammonium Perchlorate on Pulmonary Fibroblast of Mice
Objective To explore whether ammonium perchlorate(AP)could cause pulmonary fibroblast proliferation.Methods Pulmonary fibroblasts of mice were primarily cultured in vitro.After generated steadily forExpand
[Expressions of collagen in lung of rats exposed to ammonium perchlorate].
  • Jing-zhi Sun, Ming-Fen Song, K. Peng, L. Yang
  • Chemistry, Medicine
  • Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
  • 2007
The results suggest that AP has a toxic effect to promote the expressions of collagen I and collagen III mRNA in lungs of rats, and may be cause fibrosis, but there should have more suffice evidences to prove that AP is exactly compound that made lung fibrosis. Expand
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.
Findings indicate that the rat is a reliable and useful model for the study of blemoycin-induced pulmonary fibrosis and that treatment with indomethacin ameliorates the lung changes. Expand
Concentration, biosynthesis and degradation of collagen in idiopathic pulmonary fibrosis.
The results suggest that an alteration in enzymatic breakdown of collagen plays an important role in the maintenance and progression of interstitial fibrosis in this disease. Expand
The past and present of pneumoconioses.
Overall, the clinical picture of the classic pneumoconioses and their complications has not changed substantially, but their limits and links have expanded toward systemic and connective tissue disease, idiopathic pulmonary fibrosis, and antineutrophil cytoplasmic autoantibody-positive vasculitides. Expand
This short review addresses the alterations induced by bleomycin in the lung, particularly those related to the induction of fibrosis, and overviews recent literature regarding cellular and molecular mechanisms that have been identified as participants in the physiopathology ofBleomycin-induced lung fibrosis. Expand
Mechanisms of pulmonary fibrosis.
Better understanding of the mechanisms of lung repair, which include alveolar reepithelialization, myofibroblast differentiation/activation, and apoptosis, should offer more effective therapeutic options for progressive pulmonary fibrosis. Expand
Bleomycin-induced pulmonary fibrosis in rat is associated with increased expression of collagen-binding heat shock protein (HSP) 47
Overexpression of HSP47 may play a significant part in the excessive assembly of collagens and could contribute in this way to the fibrosis found in bleomycin-treated rat lungs. Expand
A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate.
A target organ effect was produced by AP in the thyroids of male and female rats at the 10 mg/kg/day level after 14 and 90 days of exposure, and changes were reversible after a nontreatment recovery period of 30 days. Expand