Pulmonary Disease due to Aspiration of Food and Other Particulate Matter: A Clinicopathologic Study of 59 Cases Diagnosed on Biopsy or Resection Specimens

  title={Pulmonary Disease due to Aspiration of Food and Other Particulate Matter: A Clinicopathologic Study of 59 Cases Diagnosed on Biopsy or Resection Specimens},
  author={Sanjay Mukhopadhyay and Anna Luise A Katzenstein},
  journal={The American Journal of Surgical Pathology},
Aspiration of particulate matter is a well-recognized complication in debilitated patients at autopsy but is not widely recognized in surgical pathology material. We have encountered a surprising number of cases on biopsy or resection specimens, and most were unsuspected clinically and pathologically. This study was undertaken to clarify clinical and pathologic features that facilitate the diagnosis of food/particulate matter aspiration pneumonia. Fifty-nine patients were identified with an… 
Histopathology of Aspiration Pneumonia Not Associated With Food or Other Particulate Matter: A Clinicopathologic Study of 10 Cases Diagnosed on Biopsy
This study adds to the earlier described literature on granulomatous reactions to food and particulate matter in the lung by alerting pathologists to other histopathologic manifestations of aspiration-induced lung injury in surgical lung biopsies.
Diffuse aspiration bronchiolitis: analysis of 20 consecutive patients*
  • Xiaowen Hu, E. Yi, J. Ryu
  • Medicine
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • 2015
Young to middle-aged subjects with recognizable predisposing factors for aspiration and who report a history of recurrent pneumonia are at increased risk for DAB, a bronchiolocentric disorder caused by recurrent aspiration.
Solitary lung masses due to occult aspiration.
Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
Asspiration-related deaths occur most commonly in the elderly with identifiable risks and presenting bilateral pulmonary infiltrates and one-third of these aspiration-related pulmonary syndromes were clinically unsuspected at the time of death.
Clinical, clinicopathologic, and radiographic findings in dogs with aspiration pneumonia: 88 cases (2004-2006).
In dogs, aspiration pneumonia was often associated with abnormalities in pulmonary auscultation in the absence of objective changes in physical examination findings, however, neutrophilia, hypoalbuminemia, and hypoxemia were frequently detected, and radiographic evidence of infiltrates in the right middle lung lobe was common.
The spectrum of lung disease due to chronic occult aspiration.
Chronic occult aspiration was associated with a number of comorbid conditions and a spectrum of radiologic and pathologic patterns, which in some patients included fibrosis.
Organizing Pneumonia
The prognosis is good in most of the cases of COP, whereas in SOP it is dependent on the underlying cause, and the treatment of choice includes corticosteroids plus treatment of the underlying disease in cases of SOP.
Airway invasive aspergillosis with organizing pneumonia: a case report and review of literature.
This is the first case of successful non-surgical treatment of IPA with SOP and the possibility of invasive airway aspergillosis concurrent with secondary organizing pneumonia is highlighted.


Diffuse bronchiolar disease due to chronic occult aspiration.
Diffuse bronchiolar disease likely represents an underrecognized form of aspiration-related lung disease and may occur in relatively young Individuals without symptoms suggestive of recurrent aspiration.
Aetiology of unresolved pneumonia.
The case notes and histopathology of 30 patients from whom lung had been resected and which had been classified as pneumonia were studied, finding very few appeared to be the consequence of an infective, pneumonic episode.
Lentil aspiration pneumonia.
A 14-year-old boy housed at a special educational school had had cerebral palsy since birth and psychosis that deepened with adolescence and died four weeks after admission of chronic granulomatous pneumonia secondary to aspiration of food, primarylegumen pulse.
Kayexalate (sodium polystyrene sulfonate) aspiration.
The patient, a 63-year-old woman, had past medical history significant for diabetes mellitus, hypertension, congestive heart failure, and a pelvic mass, and postmortem examination revealed the pelvic mass to be a small cell neuroendocrine tumor, apparently arising from the cervix.
Katzenstein and Askin's surgical pathology of non-neoplastic lung disease
Handling and Interpretation of Lung Biopsies. Acute Lung Injury Patterns: Diffuse Alveolar Damage and Bronchiolitis Obliterans-Organizing Pneumonia. Idiopathic Interstitial Pneumonia. Pathology of
Lentil aspiration pneumonia: radiographic and CT findings.
Two cases of lentil aspiration pneumonia that manifested with nodules up to 1.0 cm in diameter on radiographs and CT, simulating metastases are reported.
Diffuse interstitial pneumonitis due to aspiration of gastric contents
Two cases of interstitial pneumonitis are described which developed after the acute phase of aspiration pneum onitis, with the pulmonary lesion healing within 12 days.
Sodium polystyrene sulfonate (kayexalate) aspiration: histologic appearance and infrared microspectrophotometric analysis of two cases.
The first two cases of sodium polystyrene sulfonate aspiration in children are reported, and this material has a distinctive morphologic appearance on histologic sections, and its identity can be confirmed by Fourier transform infrared microspectrophotometry.
Relation of body position at the time of discovery with suspected aspiration pneumonia in poisoned comatose patients.
The prone position appears to be associated with a lower incidence of SAP than the lateral decubitus position in comatose poisoned patients.