Pulmonary Acinus: Understanding the Computed Tomography Findings from an Acinar Perspective

  title={Pulmonary Acinus: Understanding the Computed Tomography Findings from an Acinar Perspective},
  author={Bruno Hochhegger and Felipe Welter Langer and Klaus Loureiro Irion and Arthur Soares Souza and Jos{\'e} da Silva Moreira and Matteo Baldisserotto and Yana L. R. Pallaoro and Enrico Mattana Muller and T{\'a}ssia Machado Medeiros and Stephan Philip Leonhardt Altmayer and Edson Marchiori},
The lung acinus is the most distal portion of the airway responsible for the gas exchange. The normal acini are not visible on conventional computed tomography (CT), but the advent of micro-CT improved the understanding of the microarchitecture of healthy acini. The comprehension of the acinar architecture is pivotal for the understanding of CT findings of diseases that involve the acini. Centriacinar emphysema, for example, presents as round areas of low attenuation due to the destruction of… Expand
2 Citations
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The emphysemas: radiologic-pathologic correlations.
  • W. Foster, E. Gimenez, +4 authors P. Pratt
  • Medicine
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  • 1993
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