Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy.

@article{Zhang2009PullulanAN,
  title={Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy.},
  author={Hui-zhu Zhang and Fu-ping Gao and Ling-rong Liu and Xue-min Li and Zhi-Min Zhou and Xin-du Yang and Qi-qing Zhang},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2009},
  volume={71 1},
  pages={19-26}
}
Pullulan acetate (PA) was synthesized by the reaction of pullulan with acetic anhydride in the presence of pyridine. PA was characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance ((1)H NMR). A solvent diffusion method was employed in the current work to prepare PA nanoparticles. This technique had some advantages compared with other methods. The particle size increased from 185.7 nm to 423.0 nm with the degree of acetylation increasing from 2.71 to 3.0. Drug… CONTINUE READING