Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing.

@article{Dalal2006PullingOT,
  title={Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing.},
  author={Ravindra V Dalal and Matthew H. Larson and Keir C. Neuman and Jeff Gelles and Robert Landick and Steven M. Block},
  journal={Molecular cell},
  year={2006},
  volume={23 2},
  pages={231-9}
}
Transcriptional elongation and termination by RNA polymerase (RNAP) are controlled by interactions among the nascent RNA, DNA, and RNAP that comprise the ternary transcription elongation complex (TEC). To probe the effects of cotranscriptionally folded RNA hairpins on elongation as well as the stability of the TEC, we developed a single-molecule assay to monitor RNA elongation by Escherichia coli RNAP molecules while applying controlled loads to the nascent RNA that favor forward translocation… CONTINUE READING

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