Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.

Abstract

Spinocerebellar ataxia 7 (SCA7) is an incurable disease caused by expansion of CAG trinucleotide sequences within the Ataxin-7 gene. This elongated CAG tract results in an Ataxin-7 protein bearing an expanded polyglutamine (PolyQ) repeat. SCA7 disease is characterized by progressive neural and retinal degeneration leading to ataxia and blindness. Evidence… (More)
DOI: 10.4161/rdis.28859

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@article{Mohan2014PullingCO, title={Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.}, author={Ryan D. Mohan and Susan M. Abmayr and Jerry L. Workman}, journal={Rare diseases}, year={2014}, volume={2}, pages={e28859} }