Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages.

@article{Lee2013PulchellaminGA,
  title={Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages.},
  author={Dong-Sung Lee and Hyun Gyu Choi and Kyeong Wan Woo and Dae Gill Kang and Ho-Sub Lee and Hyuncheol Oh and Kang Ro Lee and Youn-Chul Kim},
  journal={European journal of pharmacology},
  year={2013},
  volume={715 1-3},
  pages={
          123-32
        }
}
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
TLDR
Results suggest the involvement of HO-1/CO system in the antiallodynic and antihyperalgesic effect of H. procumbens in carrageenan-induced inflammatory pain.
Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
TLDR
The therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson’s disease and hepatic fibrosis is discussed, and an updated, comprehensive list of natural HO- 1 inducers in foodstuff and medicinal herbs categorized by their chemical structures is provided.
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer’s disease model of differentiated neuroblastoma cell line
TLDR
Cell viability tests revealed significant neuroprotection against β-amyloid toxicity in both 24 and 48 hours and the Hoechst 33258 fluorescence staining method showed a significant decrease in necrotic deaths after farnesene application in the cell cultures.
Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.
TLDR
Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.
TLDR
Classifying bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing NRF2 to provide favorable effects in experimental models of chronic diseases improve the treatment efficacy.
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting
TLDR
The role of Nrf2 pathway and its modulators in psychiatric disorders is explored to find immense potential opportunities for these modulators to become a novel therapeutic option.
Constituent Composition of Essential Oil from Saussurea pulchella
Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2016, pp. 970–971.

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