Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages.

  title={Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages.},
  author={Dong-Sung Lee and Hyun Gyu Choi and Kyeong Wan Woo and Dae Gill Kang and Ho-Sub Lee and Hyuncheol Oh and Kang Ro Lee and Youn-Chul Kim},
  journal={European journal of pharmacology},
  volume={715 1-3},
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
Results suggest the involvement of HO-1/CO system in the antiallodynic and antihyperalgesic effect of H. procumbens in carrageenan-induced inflammatory pain.
Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
The therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson’s disease and hepatic fibrosis is discussed, and an updated, comprehensive list of natural HO- 1 inducers in foodstuff and medicinal herbs categorized by their chemical structures is provided.
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer’s disease model of differentiated neuroblastoma cell line
Cell viability tests revealed significant neuroprotection against β-amyloid toxicity in both 24 and 48 hours and the Hoechst 33258 fluorescence staining method showed a significant decrease in necrotic deaths after farnesene application in the cell cultures.
Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.
Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.
Classifying bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing NRF2 to provide favorable effects in experimental models of chronic diseases improve the treatment efficacy.
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting
The role of Nrf2 pathway and its modulators in psychiatric disorders is explored to find immense potential opportunities for these modulators to become a novel therapeutic option.
Constituent Composition of Essential Oil from Saussurea pulchella
Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2016, pp. 970–971.


Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2.
Whether CO can regulate (and if so, to delineate the mechanism by which CO regulates) LPS-induced COX-2 expression in macrophages is examined to act as an important regulator of inflammation by virtue of its ability to regulate C/EBPs.
Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
Results indicate that CO liberated by CORM‐2 andCORM‐3 significantly suppresses the inflammatory response elicited by LPS in cultured macrophages and suggest that CO carriers can be used as an effective strategy to modulate inflammation.
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
Compounds 1-8 are potential cytotoxic agents but without significant antibacterial effect, and the structures of the new compounds were elucidated from spectroscopic and/or X-ray data interpretations.
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
It is suggested that the ‘cachectin’ and ‘TNF’ activities of murine macrophage conditioned medium are attributable to a single protein, which modulates the metabolic activities of normal as well as neoplastic cells through interaction with specific high-affinity receptors.
Heme oxygenase-1: unleashing the protective properties of heme.