Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells.

@article{Wang2014PuerarinCS,
  title={Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells.},
  author={Yue Wang and Cheng Yang and Wen Li Xie and Yan Wei Zhao and Zong Min Li and Wei Sun and Ling Zhi Li},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2014},
  volume={21 8-9},
  pages={1032-6}
}
Puerarin, a daidzein-8-C-glucoside, is the major isoflavone glycoside found in the Chinese herb radix of Pueraria lobata (Willd.) Ohwi, and has received increasing attention because of its possible role in the prevention of osteoporosis. In our previous studies, puerarin reduced the bone resorption of osteoclasts and promoted long bone growth in fetal mouse in vitro. Further study confirmed that puerarin stimulated proliferation and differentiation of osteoblasts in rat. However, the mechanisms… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Molecular signaling mechanisms behind polyphenol-induced bone anabolism

Phytochemistry Reviews • 2017
View 15 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…