Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation.

@article{Zhang2016PuerarinPL,
  title={Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation.},
  author={Yun Zhang and Ming Yan and Qing-Feng Yu and Pei-Fan Yang and Hai-dong Zhang and Yong-Hong Sun and Zhi-fen Zhang and Yun-Feng Gao},
  journal={Biological & pharmaceutical bulletin},
  year={2016},
  volume={39 12},
  pages={2028-2035}
}
Osteolysis induced by chronic Gram-negative bacterial infection underlies many bone diseases such as osteomyelitis, septic arthritis, and periodontitis. Drugs that inhibit lipopolysaccharide (LPS)-induced osteolysis are critically needed for the prevention of bone destruction in infective bone diseases. In this study, we assessed the effect of puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis and bone loss. Our in vitro study showed that… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2014

Similar Papers

Loading similar papers…