Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway.

@article{Xu2019PuerarinDC,
  title={Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway.},
  author={Xudong Xu and Ruhong Jiang and Mengmeng Chen and Mengmeng Dong and Qiang Liu and Hui Cheng and Kuangshi Zhou and Laite Chen and Miaomiao Li and Chenyang Jiang},
  journal={Journal of cardiovascular pharmacology},
  year={2019},
  volume={73 6},
  pages={
          373-382
        }
}
Puerarin is used to treat cardiovascular diseases due to its anti-inflammatory and antifibrotic effects. However, its mechanism of action in atrial fibroblasts is unknown. In this study, we investigated the autophagy pathway and molecular changes in angiotensin II (AngII)-stimulated atrial fibroblasts in response to puerarin treatment. Atrial fibroblasts were cultured and then subjected to stimulation with AngII and puerarin or other chemical drugs (3-MA, CQ, and SP600125). Quantitative real… CONTINUE READING