Publication bias in clinical research

@article{Easterbrook1991PublicationBI,
  title={Publication bias in clinical research},
  author={Philippa Easterbrook and R Gopalan and Jesse A. Berlin and David R. Matthews},
  journal={The Lancet},
  year={1991},
  volume={337},
  pages={867-872}
}
Publication bias: evidence of delayed publication in a cohort study of clinical research projects
TLDR
The study results support the need for prospective registration of clinical research projects to avoid publication bias and also support restricting the selection of trials to those started before a common date in undertaking systematic reviews.
Publication bias in the medical literature: A review by a Canadian research ethics board
TLDR
The results suggest that a different approach is required to reduce publication bias and the role that REBs and peer-reviewed journals might play requires further exploration.
[The relation between publication bias and clinical trials funding].
Introducing prospective manuscript review to address publication bias.
  • L. Mell, A. Zietman
  • Psychology
    International journal of radiation oncology, biology, physics
  • 2014
Publication bias in reproductive research.
TLDR
It is concluded that a considerable publication deficit, but not a publication bias, exists for RCT in reproductive research.
Publication and non-publication of clinical trials: longitudinal study of applications submitted to a research ethics committee.
TLDR
Large multi-centre trials with non-commercial funding were more likely to be published than other trials, but most trials were funded by industry.
Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias.
TLDR
The percentage of randomized controlled trials presented at a major pediatric scientific meeting that were subsequently published as full-length articles was measured to investigate factors associated with publication, and to describe the variables that change from abstract to manuscript form.
Assessment of Publication Bias
  • S. Schulzke
  • Biology, Psychology
    Principles and Practice of Systematic Reviews and Meta-Analysis
  • 2021
TLDR
This chapter covers the reasons for publication bias and its influence on effect estimates, and the methods for assessing and handling this risk.
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References

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Publication bias and clinical trials.
A measure to aid in the interpretation of published clinical trials.
  • C. Begg
  • Psychology
    Statistics in medicine
  • 1985
TLDR
A model is developed which permits estimation of the potential magnitude by which the reported efficacy of a treatment might be inflated, termed the publication bias, which depends on the sample size of the study and the number of similar studies conducted concurrently.
Retrospective and prospective identification of unpublished controlled trials: lessons from a survey of obstetricians and pediatricians.
TLDR
It was concluded that publication bias will not be addressed successfully by attempts to obtain information about unpublished trials retrospectively, but prospective registration of trials at inception appears to be a feasible approach to reducing publication bias and its adverse consequences.
Confronting publication bias: a cohort design for meta-analysis.
  • R. Simes
  • Medicine
    Statistics in medicine
  • 1987
TLDR
A model is developed for pooling the results of clinical trials which is free from publication bias and is illustrated using the International Cancer Research Data Bank (ICRDB) registry of cancer clinical trials to evaluate the effect of chemotherapy on survival in advanced ovarian cancer.
Source of funding and outcome of clinical trials
  • R. Davidson
  • Medicine, Psychology
    Journal of general internal medicine
  • 1986
TLDR
Few trials supported by pharmaceutical manufacturers favored traditional therapy; some reasons for this finding may include selection of drugs likely to be proven efficacious, Type II errors (false-negative studies), and fear of discontinuation of funding should such studies be submitted.
Publication bias: the case for an international registry of clinical trials.
  • R. Simes
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1986
TLDR
A model is proposed for reviewing clinical trial results which is free from publication bias based on the selection of trials registered in advance in a registry, and the value and importance of an international registry of all clinical trials are illustrated.
Publication bias : a problem in interpreting medical data
Publication bias, the phenomenon in which studies with positive results are more likely to be published than studies with negative results, is a serious problem in the interpretation of scientific
A cohort study of summary reports of controlled trials.
TLDR
The hypotheses that clinical trials would be more likely to be followed by full reports if, on the basis of the information provided in the summary report, the trial was judged to be methodologically sound, the results favored the test treatment, and the sample size was relatively large are tested.
Estimation issues in clinical trials and overviews.
TLDR
This article examines a number of issues which affect the use and interpretation of conventional estimation methods and concludes that the emphasis on estimation methods is a powerful tool for encouraging larger sample sizes.
Sensitivity and specificity of clinical trials. Randomized v historical controls.
The relative accuracy of randomized control trials (RCTs) and historical control trials (HCTs) in determining effective therapies has not been compared since there is no external verification of
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