Public health. A sound rationale needed for phase III HIV-1 vaccine trials.

@article{Burton2004PublicHA,
  title={Public health. A sound rationale needed for phase III HIV-1 vaccine trials.},
  author={Dennis R. Burton and Ronald C Desrosiers and Robert W. Doms and Mark B. Feinberg and Robert C. Gallo and Beatrice Hahn and James A Hoxie and Eric Hunter and Bette T Korber and Alan L. Landay and Michael M. Lederman and Judy Lieberman and Joseph M McCune and John P. Moore and Neal Nathanson and Louis J. Picker and Douglas R Richman and Charles R. Rinaldo and Mario Stevenson and David I. Watkins and Steven M. Wolinsky and Jerome A. Zack},
  journal={Science},
  year={2004},
  volume={303 5656},
  pages={316}
}
T he need for a human immunodeficiency virus–1 (HIV-1) vaccine is unques-tioned, and we strongly support its development as the highest AIDS research priority. We have a concern about the wisdom of the U.S. government's sponsoring a recently initiated phase III trial in Thailand of a vaccine made from the live-replicating canarypox vector ALVAC (from Aventis Pasteur) with a boost of monomeric gp120 (from VaxGen) (1). The original aim of this trial was to determine whether a combination of… CONTINUE READING

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Enhanced online at www.sciencemag.org/cgi/ content/full

Enhanced online at www.sciencemag.org/cgi/ content/full

Sound Rationale Needed for Phase III HIV-1 Vaccine Trials

P U B L I C H E A L T H
Sound Rationale Needed for Phase III HIV-1 Vaccine Trials

Zack 18 POLICY FORUM 1 The Scripps Research Institute

Mario Stevenson, David I Watkins, Steven M Wolinsky, Jerome A
Gladstone Institute for Virology and Immunology

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