Public health significance of elevated homocysteine.

  title={Public health significance of elevated homocysteine.},
  author={Jacob S Selhub},
  journal={Food and nutrition bulletin},
  volume={29 2 Suppl},
Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation, which requires folic acid and vitamin B12 coenzymes; and transsulfuration, which requires pyridoxal-5'-phosphate, the vitamin B6 coenzyme. Data from a number of laboratories suggest that mild elevations of homocysteine in plasma are a risk factor for occlusive vascular disease. In the Framingham studies, we have shown that plasma homocysteine concentration is inversely related to the… CONTINUE READING
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