Public epitopes and the antigenic structure of the HLA molecules.

  title={Public epitopes and the antigenic structure of the HLA molecules.},
  author={Glenn E. Rodey and Thomas C. Fuller},
  journal={Critical reviews in immunology},
  volume={7 3},
Simplified procedures for determining amino acid sequences in proteins and nucleotide sequences in DNA have rapidly expanded the number of MHC molecules for which primary amino acid structure is known. These molecules will be especially valuable as tools to study the structure-function relationships of globular proteins because of the extensive polymorphism of genes coding the MHC genes products. The general three-dimensional structure of class I MHC molecules was recently deduced, but the more… CONTINUE READING