Public Health Research Resulting from One of the World’s Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review

  title={Public Health Research Resulting from One of the World’s Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review},
  author={Elena K{\"o}ckerling and Laura Karrasch and Aparna Schweitzer and Oliver Razum and G{\'e}rard Krause},
  journal={Frontiers in Public Health},
In 2011, Germany experienced one of the largest outbreaks of entero-hemorrhagic Escherichia coli (EHEC) ever reported. Four years thereafter, we systematically searched for scientific publications in PubMed and MEDPILOT relating to this outbreak in order to assess the pattern of respective research activities and to assess the main findings and recommendations in the field of public health. Following PRISMA guidelines, we selected 133 publications, half of which were published within 17 months… Expand

Topics from this paper

Retrospective assessment of rapid outbreak investigation for gastrointestinal diseases using only cases and background exposure data
The case-background method, a development of the case-case design, can be used to assist with hypothesis generation or when a case-control study may not be possible to carry out. Expand
Development of a multiplex PCR targeting eae, stx and cdt genes in genus Escherichia and detection of a novel cdtB gene in Providencia rustigianii.
The results indicate that the m-PCR is useful for surveillance of eae, stx and cdt gene-positive bacteria, not only EPEC, STEC and E. albertii but also P. rustigianii. Expand
Fruit Decay to Diseases: Can Induced Resistance and Priming Help?
A review of the successful activity of post-harvest-induced resistance (IR) through the use of safer chemicals from biological origin, biocontrol, and physical means, and how its long-lasting and broad-spectrum nature could contribute to fruit resistance is explored. Expand
On the strong connection between nanoscale adhesion of Yad fimbriae and macroscale attachment of Yad-decorated bacteria to glycosylated, hydrophobic and hydrophilic surfaces.
The interaction forces operational between Yad fimbriae expressed by genetically modified E. coli and self-assembled monolayers (SAM) differing in terms of charge, hydrophobicity or the nature of decorating sugar units are quantified by Single Molecule Force Spectroscopy on the nanoscale. Expand


[The 2011 HUS epidemic in Germany. Challenges for disease control: what should be improved?].
From May to July 2011 [corrected] the world's largest outbreak of hemolytic uremic syndrome (HUS) occurred in northern Germany with dramatic consequences for the population, the health care systemExpand
Epidemiological analysis of a cluster within the outbreak of Shiga toxin-producing Escherichia coli serotype O104:H4 in Northern Germany, 2011.
In May 2011 one of the worldwide largest outbreaks of haemolytic uraemic syndrome (HUS) and bloody diarrhoea caused by Shiga toxin-producing Escherichia coli (STEC) serotype O104:H4 occurred in Germany, with sprouts as the source of infection. Expand
[Management of patients with EHEC/HUS. Lessons and perspectives from clinical infectious disease specialists].
  • W. Kern
  • Medicine
  • Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
  • 2013
An expert panel of the German Society for Infectious Diseases in cooperation with representatives of other learned societies and health institutions has drafted and consented guidelines regarding the previous recommendations of withholding antibiotic therapy and regarding rational measures for prevention of invasive meningococcal disease after treatment with the monoclonal antibody eculizumab. Expand
Multidisciplinary response to the Escherichia coli 0104 outbreak in Europe.
Timely and accurate risk assessment, management, and communication were vital in protecting the DoD population during this outbreak and there were no cases in DoD-related personnel. Expand
TV news and concerns about - the EHEC-outbreak 2011 in Germany.
A clear positive correlation of the frequency of TV reports dealing with the epidemic disease outbreak and the rate of outpatient consultations in emergency rooms because of diarrhoea is suggested and could make an important contribution for future discussions. Expand
Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany.
In this outbreak, caused by an unusual E. coli strain, cases of the hemolytic-uremic syndrome occurred predominantly in adults, with a preponderance of cases occurring in women. Expand
Symptoms and Clinical Course of EHEC O104 Infection in Hospitalized Patients: A Prospective Single Center Study
EHEC O104:H4 infections differ markedly from earlier reports on O157:H7 induced enterocolitis in regard to epidemiology, symptomatology, and frequency of complications, and a standard of practice for clinical monitoring is recommended. Expand
Escherichia coli O104:H4 outbreak in Germany--clarification of the origin of the epidemic.
The analysis of the unusual GHUSEC outbreak shows that the present official assumption of its natural origin is questionable and pointed out to a probability that the pathogen could have also been introduced accidentally or intentionally in the food chain. Expand
Duration of fecal shedding of Shiga toxin-producing Escherichia coli O104:H4 in patients infected during the 2011 outbreak in Germany: a multicenter study.
  • R. Vonberg, M. Höhle, +24 authors S. Suerbaum
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2013
STEC O104:H4 is usually eliminated from the human gut after 1 month, but may sometimes be excreted for several months, and proper follow-up of infected patients is important to avoid further pathogen spread. Expand
E. coli O104:H4 outbreak and haemolytic-uraemic syndrome.
A literature review is made to assess the state of the art in STEC-haemolytic-uraemic syndrome (HUS) epidemiology, pathogenesis, management and prognosis, focusing on critically ill adults. Expand