Pubertal alterations in growth and body composition: IX. Altered spontaneous secretion and metabolic clearance of growth hormone in overweight youth.

@article{Roemmich2005PubertalAI,
  title={Pubertal alterations in growth and body composition: IX. Altered spontaneous secretion and metabolic clearance of growth hormone in overweight youth.},
  author={James N Roemmich and Pamela A Clark and Arthur L. Weltman and Johannes D. Veldhuis and Alan D Rogol},
  journal={Metabolism: clinical and experimental},
  year={2005},
  volume={54 10},
  pages={1374-83}
}
Deconvolution analysis was used to determine 12-hour spontaneous nocturnal growth hormone (GH) secretion and GH half-life in lean (body mass index, <85th percentile; n = 39) and overweight (body mass index, > or =85th percentile; n = 18) youth. The integrated GH concentration, GH burst mass, and half-life were lower (P < .05) in overweight than in lean youth. For each unit increase in percentage of body fat, integrated serum GH concentrations, secretory burst mass, and half-life declined by 83… CONTINUE READING

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