Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.

@article{BardChapeau2011Ptpn11Shp2AA,
  title={Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.},
  author={Emilie Anne Bard-Chapeau and Shuangwei Li and Jin Ding and Sharon S. Zhang and Helen He Zhu and Frederic Princen and Diane D Fang and Tao Han and B{\'e}atrice Bailly-Ma{\^i}tre and Valeria Poli and Nissi M. Varki and Hongyang Wang and Gen-sheng Feng},
  journal={Cancer cell},
  year={2011},
  volume={19 5},
  pages={
          629-39
        }
}
The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced… CONTINUE READING
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