Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells.

@article{Wang2012PterostilbeneSI,
  title={Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells.},
  author={Yanshang Wang and Ling Ling Ding and Xian Wang and Jingyi Zhang and Weidong Han and Lifeng Feng and Jie Sun and Hong Chuan Jin and Xiao Jia Wang},
  journal={American journal of translational research},
  year={2012},
  volume={4 1},
  pages={44-51}
}
As a nature phytoalexin found in grapes, resveratrol has been proposed as a potential drug for cancer chemoprevention and treatment. However, its poor bioavailability limits its potential clinical application. Pterostilbene, the natural dimethylated analog of resveratrol with greater bioavailability, was confirmed to inhibit tumor growth both in vivo and in vitro, demonstrating its potential for further clinical application. In the current study, we found that pterostilbene could markedly… CONTINUE READING
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