Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.

  title={Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.},
  author={Martina La Spina and Gabriele Sansevero and L. Biasutto and M. Zoratti and R. Peruzzo and N. Berardi and Alessandro Sale and M. Azzolini},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={52 2},
BACKGROUND/AIMS Pterostilbene (Pt; trans-3,5-dimethoxy-4'-hydroxystilbene) is a natural phenol found in blueberries and grapevines. It shows remarkable biomedical activities similar to those of resveratrol. Its high bioavailability is a major advantage for possible biomedical applications. The goal of the study was to evaluate the effects of chronic pterostilbene administration on cognitive performance in aged rats with mild cognitive impairment. METHODS 18-month-old animals were subjected to… Expand
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Characterization of Effectiveness in Concerted Ih Inhibition and IK(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4′-hydroxystilbene), a Stilbenoid
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Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
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Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic.
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Pharmacokinetics and tissue distribution of pterostilbene in the rat.
Tissue distribution of Pt and its major metabolite, pterostilbene-4'-sulfate (Pt-S), in rats after oral administration is determined, finding a high fraction of nonmetabolized Pt in the brain, given the reports of its activity at the level of the central nervous system. Expand
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In order to reveal information on absorption, metabolism, and the consequent bioavailability of resveratrol, different research approaches were performed, including in vitro, ex vivo, and in vivo models, all of which are considered in this review. Expand
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This review provides an overview of current findings from animal studies assessing the impact of high fat diets supplemented with blueberries, blackberries, grapes and jaboticaba berries on cognitive performance and neuroprotection. Expand
New natural amino acid‐bearing prodrugs boost pterostilbene's oral pharmacokinetic and distribution profile
  • M. Azzolini, A. Mattarei, +6 authors L. Biasutto
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2017
Experiments using Caco‐2 cells as an in vitro model for human intestinal absorption suggest that the prodrug could have promising absorption profiles also in humans; its uptake is partly due to passive diffusion, and partly mediated by H+‐dependent transporters expressed on the apical membrane of enterocytes, such as PepT1 and OATP. Expand