Pterin transport and metabolism in Leishmania and related trypanosomatid parasites.

@article{Ouellette2002PterinTA,
  title={Pterin transport and metabolism in Leishmania and related trypanosomatid parasites.},
  author={Marc J. Ouellette and Jolyne Drummelsmith and Amal El-Fadili and Christoph K{\"u}ndig and D. D. Richard and Ga{\'e}tan Roy},
  journal={International journal for parasitology},
  year={2002},
  volume={32 4},
  pages={385-98}
}
The folate metabolic pathway has been exploited successfully for the development of antimicrobial and antineoplasic agents. Inhibitors of this pathway, however, are not useful against Leishmania and other trypanosomatids. Work on the mechanism of methotrexate resistance in Leishmania has dramatically increased our understanding of folate and pterin metabolism in this organism. The metabolic and cellular functions of the reduced form of folates and pterins are beginning to be established and… CONTINUE READING

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